Glossary

Hardware and/or software applications created or stored by the use of outmoded or obsolete languages, platforms, and techniques, in which a company may have already invested considerable resources and which has retained its importance. Legacy systems typically perform critical operations in companies for many years even though they may no longer use state-of-the-art technology. Replacing legacy systems can be disruptive and therefore requires careful planning and appropriate migration support from the manufacturer.

A person authorized either by statute or by court appointment to make decisions on behalf of another person. In human subjects’ research, an individual or judicial or other body authorized under applicable law to consent on behalf of a prospective subject to the subject's participation in the procedure(s) involved in the research.45CFR46.102 (c)

A genus of bacteria, some species of which have caused a type of pneumonia called Legionnaires Disease.

Lower Explosive Limit

The LEL depends on the mixture of product vapor and oxygen necessary to produce fire of explosion in the presence of an ignition source. LEL is expressed as the percent of product vapor by volume in air.

Light Emitting Polymer

A genus of the family Treponemataceae, thin coiled organisms, flagellated at the extremities, one or both of which are bent back like a hook. Both pathogenic and innocent forms have been isolated.

Review of challenges or opportunities from previous projects or a summation of those experienced within the current or future projects.

A concentration of chemical in air that will kill 50% of the test animals inhaling it.

The dose of a chemical that will kill 50% of the test animals receiving it. The chemical may be given by mouth (oral), applied to the skin (dermal), or injected (parenteral). A given chemical will generally show different LD50 values depending on how it is given to the animals. It is a rough measure of acute toxicity.

The quality of being lethal; mortality.

These are letters – often referred to as “Dear Doctor” letters – that are developed by drug companies often with input from FDA. The letters educate health care professionals about new and important drug information.

Cancer that begins in developing blood cells in the bone marrow.

A general name for white, nucleated blood cells found in the blood and lymphatic tissue.

Local Exhaust Ventilation

The level of protection required for an area based on an assessment by the manufacturer of contamination risk.

The level of protection required for an area, based upon the exposure and the point in the manufacturing process during which the exposure occurs.

Large Granular Lymphocyte

Luteinizing Hormone

Liquid Handling Module (Chromatography)